Using STZ-induced diabetes as a T1D model, BPA altered the expression of genes regulating Ca2+ homeostasis, leading to endoplasmic reticulum stress and β-cell dysfunction (109); however, another report using this model showed that BPA restored the glucose intolerance and restored the insulin transcriptional regulators Pdx1, Mafa, and NeuroD1 (110). This evidence concerns the gene INS and diabetes mellitus.