INS and Glucose intolerance: Using STZ-induced diabetes as a T1D model, BPA altered the expression of genes regulating Ca2+ homeostasis, leading to endoplasmic reticulum stress and β-cell dysfunction (109); however, another report using this model showed that BPA restored the glucose intolerance and restored the insulin transcriptional regulators Pdx1, Mafa, and NeuroD1 (110).