ApoE*ε2+ was significantly associated (p = 0.030, OR = 0.24, 95% CI 0.06–0.87) with overweight and obesity (BMI>25.kg/m2) and Castelli risk index (p = 0.024, OR = 11.26, 95% CI .37–92.30) in females. Here, APOE is linked to obesity disorder.