Linear regression models that included sex, age, BMI, smoking status, and habitual alcohol drinking as independent variables were used to assess sex differences in the 10 metabolic parameters related to obesity, including BS, HbA1c, UA, LDL/HDL cholesterol, TG, systolic/diastolic BP, AST, and ALT. This evidence concerns the gene GPT and obesity due to melanocortin 4 receptor deficiency.