NFKBIZ and neoplasm: The Lin−/c-Kit+/Sca-1+/CD34+ cells from the spleen of tumor-bearing animals expressed a unique inflammatory gene signature, including Tnf, Cxcl2, Nfkbiz, Nfkbia, compared to control BM (CBM) cells or tumor-bearing BM (TBM) cells (Fig 2E–2H).