CCR5 and AIDS: Thereafter, the stHIV-1sv strain was adapted in vivo for several passages, and its descendants containing several mutations in structural and accessory genes such as vpu, gag-CA, or env have shown adaptations to other macaque-specific restriction factors tetherin, MX2, or the use of the viral coreceptor CCR5, respectively; they still cannot replicate well at chronic stage and induce AIDS in PTMs (Hatziioannou et al. 2014; Schmidt et al. 2019).