Considering that stHIV-1sv is a more virulent strain than HIV-1NL4-R3A in NPMs, and the ISGs are mostly upregulated at early time of infection in response to the viral invasion, we extracted the ISGs which were particularly upregulated at 1 wpi and 2 wpi during the stHIV-1 infection and retrieved a small cluster of them, including IFI27, IFI6, MX1, MX2, RSAD2, IFI44, OASL, HERC5, IFNG, and IFIT3(fig. This evidence concerns the gene IFNG and infection.