MX2 and AIDS: An indirect indication was stHIV-1sv adaptation to another species of PTMs, southern PTMs, wherein the amino acid changes in viral Vpu, and Gag-capsid proteins have obtained enhanced antagonism to macaque restrict factors tetherin, and MX2, respectively, but the viral swarms or clones did not replicate well and induce the macaques to AIDS states (Hatziioannou et al. 2014; Schmidt et al. 2019), implying that some undiscovered host factors still hamper HIV-1 replication and pathogenicity in that species.