Next-generation sequencing (NGS) platforms have not been universally established in our country for mCRC molecular studies and are useful tools to analyze RAS, BRAF, and HER2 alterations simultaneously and providing information regarding tumor hyper-mutation burden (TMB), as well as complementary diagnostic information about Lynch syndrome by mutational study of the MMR and EPCAM genes [27]. The gene discussed is BRAF; the disease is neoplasm.