Healthy children who are first-degree relatives of individuals with a germline disease-causing TP53 variant should be offered predictive testing if the genetic variant confers a high cancer risk in childhood (reported in families with childhood cancers carrying the same pathogenic variant, childhood cancers have been observed within the family, or it is a dominant-negative missense variant) [4]. The gene discussed is TP53; the disease is childhood malignant neoplasm.