RYR1 and heart failure: For example, Brody myopathy characterized by mutations in SERCA1 leads to muscle weakness (Molenaar et al. 2020), Darier disease characterized by mutations in SERCA2 is associated with increased risk of heart failure, (Bachar-Wikstrom et al. 2020) and ryanodine receptor 1 related myopathies are associated with muscle weakness and atrophy (Greer et al. 2022).