13 of the 21 family members were found to be highly expressed in HCC tumor samples, including S100A1, S100A2, S100A3, S100A4, S100A5, S100A6, S100A10, S100A11, S100A13, S10016, S100P, and S100Z (Figure 1A). Here, S100Z is linked to hepatocellular carcinoma.