In addition, single or combined synthetic oral antidiabetic medicines such as biguanides, sulfonylureas, dipeptidyl peptidase-IV (DPP-IV) inhibitors, thiazolidinediones, disaccharidase inhibitors, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) analogs, or/and insulin can be employed as insulin secretagogues/insulinotropic agents for the management of diabetes mellitus [8]. This evidence concerns the gene INS and diabetes mellitus.