NRF1 and infection: Other transcription factors with induced eGRN activity in both wound clusters include the Cyclic-AMP response element binding protein A (CrebA, CREB3L2 ortholog, involved in resistance to infection), Cap'n'collar (Cnc, Nrf1/2 ortholog, involved in oxidative stress response), and Cryptocephal (Crc, ATF4 ortholog, involved in unfolded protein response) (Figure 3a), three basic-leucine zipper (bZip) TFs known to be involved in stress response (Brock et al., 2017; Brown et al., 2021; Ragheb et al., 2017; Sorge et al., 2020; Sykiotis and Bohmann, 2008; Troha et al., 2018).