Despite higher noise levels in the tumor clustering analysis, the detected cellular heterogeneity in rasV12scrib-/- tumors would corroborate the results from a recent study by Jaiswal et al., 2022, which depicts the emergence of cellular heterogeneity in early-stage rasV12scrib-/- tumors via a JNK/STAT regulatory feedback loop (Jaiswal et al., 2022). Here, MAPK8 is linked to neoplasm.