CASP3 and ischemia: In another study, a significant increase in caspase-3 activation was observed in granular cells in mature antral follicles and inflammatory cells in the stromal region in the ischemia group, while they showed negative expression of caspase-3 expression in antral follicle cells and granular cells around the antral follicle in the application of antioxidants such as rosmarinic acid25.