However, although PD‐L1 mono blockade did not cause significant dysfunction in hematological tests, the dual CD47/PD‐L1 blockade of CPA not only induced anemia in 100% (5/5) of the mice due to a higher dosage of CD47 antibody administration but also significantly increased the ALT and AST with higher antibody administration (Figure 6A–C). Here, CD274 is linked to anemia.