More and more studies have highlighted the pivotal role of ferroptosis in HCC and the strict correlation between some ferroptosis modulators activity in cancer development such as p53, retinoblastoma (Rb) protein, and NRF2 (Jennis et al., 2016; Louandre et al., 2015; Nie et al., 2018; Sun et al., 2016b; p. 2). The gene discussed is NFE2L2; the disease is cancer.