SOD1 and cancer: Indeed, cancer cells upregulate several Cu2+ chaperones such as the copper chaperone for SOD1 (CCS), which binds cytosolic Cu2+ and transfers it to SOD1, and pharmacological disruption of this process can have therapeutic effects on cancer as it reduces uncontrolled cell proliferation (Li et al., 2019b; Rae et al., 1999; Wang et al., 2015).