The study was able to determine ten ferroptosis-related genes signature in CRC: transcription factor AP-2 gamma (TFAP2C), solute carrier family 39 member 8 (SLC39A8), nitric oxide synthase 2 (NOS2), hepcidin antimicrobial peptide (HAMP), growth differentiation factor 15 (GDF15), farnesyl-diphosphate farnesyltransferase 1 (FDFT1), cyclin dependent kinase inhibitor 2A (CDKN2A), ALOX12, aldo-keto reductase family 1 member C1 (AKR1C1), and ATPase H+ transporting V1 subunit G2 (ATP6V1G2). The gene discussed is AKR1C1; the disease is colorectal carcinoma.