More and more studies have highlighted the pivotal role of ferroptosis in HCC and the strict correlation between some ferroptosis modulators activity in cancer development such as p53, retinoblastoma (Rb) protein, and NRF2 (Jennis et al., 2016; Louandre et al., 2015; Nie et al., 2018; Sun et al., 2016b; p. 2). This evidence concerns the gene TP53 and cancer.