Brown et al. recently described extracellular matrix (ECM) detachment as a physiologic trigger of ferroptosis in BC cells due to consequent GPX4 inhibition; however, α6β4 integrin can help cells escape this process by activating STAT3 and suppressing ACSL4 expression, exerting a protective function for membrane lipids integrity (Brown et al., 2017). The gene discussed is GPX4; the disease is breast cancer.