Inhibition of ALOX5 operated by the microsomal glutathione S-transferase 1 (MGST1) was observed to be consistent in human pancreatic ductal adenocarcinoma (PDAC) cell lines, remarking on ALOX5 role as a positive regulator of ferroptosis (Kuang et al., 2021). This evidence concerns the gene ALOX5 and pancreatic ductal adenocarcinoma.