TFRC and glioblastoma: In U251 glioblastoma cells, artesunate augmented the expression levels of Divalent Metal (Ion) Transporter 1 (DMT1), TfR, NCOA4, and FT, decreased the expression of FPN1 and GPX4, and additionally activated ferroptosis through the MAPK/ERK and MAPK/p38 pathways as a consequence of the increased ROS content (Song et al., 2022).