Interestingly, FSP1 negative regulation of ferroptotic process is independent of intracellular GSH and oxidizable fatty acid content, GPX4 enzymatic activity, and ACSL4 expression, revealing a non-canonical mechanism behind its function; thus, FSP1 inhibition could represent a valid strategy to sensitize cancer cells to ferroptosis (Shi et al., 2021). The gene discussed is GPX4; the disease is cancer.