IL4 and neoplasm: In the TME, TAMs usually exhibit an anti‐inflammatory and immunosuppressive M2‐like phenotype, which is associated with immune evasion and tumor progression.[40] To explore the effect of CH‐OD‐SSZ hydrogel on macrophage polarization, mouse bone marrow‐derived macrophages (BMDMs) were isolated and polarized to M2‐like phenotype using IL‐4, and then exposed to PBS, SSZ, CH‐OD, or CH‐OD‐SSZ hydrogel.