CDH2 and Miyoshi myopathy: 38). A large number of non-peptidyl peptidomimetics of ADH-1 have been recently identified (Refs 93, 94), for example, the small-molecule LCRF-0006 is an ADH-1 peptidomimetic that inhibits CDH2 function, induces apoptosis in multiple myeloma (MM) and synergises with bortezomib to enhance MM cell death in vitro (Ref. 93).