71). CDH2 regulates Wnt/β-catenin signalling, a conserved pathway that plays a role in physiological processes, including differentiation, proliferation and cell fate determination. CDH1 is known to inhibit the activation of the Wnt pathway, and in ALL CDH1 has been shown to be decreased, indicating Wnt pathway activation (Ref. 76). Additionally in ALL, Akt has been shown to inhibit GSK3β leading to the activation of β-catenin (Ref. 80). Here, CDH1 is linked to acute lymphoblastic leukemia.