In particular, the peptidomimetic-designated Compound 15, a piperidin-4-amine which acts as a CDH2 antagonist, has been shown to induce apoptosis of MM, glioblastoma and pancreatic cancer cells, as well as fibroblast and cancer-associated death in vitro (Refs 38, 96). The gene discussed is CDH2; the disease is Miyoshi myopathy.