38). A large number of non-peptidyl peptidomimetics of ADH-1 have been recently identified (Refs 93, 94), for example, the small-molecule LCRF-0006 is an ADH-1 peptidomimetic that inhibits CDH2 function, induces apoptosis in multiple myeloma (MM) and synergises with bortezomib to enhance MM cell death in vitro (Ref. 93). This evidence concerns the gene ADH1A and AL amyloidosis.