Lycopene up‐regulated glutathione S‐transferase pi gene (GSTP1) expression and demethylases the GSTP1 in MCF‐7, MDA‐MB‐468 cells, whereas induced RARbeta2 and HIN‐1 genes demethylation in BC (MCF10A) cells in a dose‐dependent manner.168. Here, GSTP1 is linked to breast cancer.