Therefore, natural phytochemicals are potent oncogenic inhibitors by regulating inflammation through regulating TNF‐α mediated NF‐κB, IκB kinase, COX‐2 and MMP‐8, IL‐1β, TNF‐α, phospho‐Akt, phosphor‐p65, and NF‐κB‐binding activity in numerous cancer models. This evidence concerns the gene NFKB1 and cancer.