The details mechanism of anti‐cancer activity from in vitro, preclinical and clinical studies suggested that phytochemicals mediate their anti‐cancer efficacy through targeting apoptosis proteins, including anti‐apoptotic proteins (Bcl‐2) and apoptotic proteins (Bax, Bak, Bad, and Caspase), arresting cell cycle and proliferation. The gene discussed is BCL2; the disease is cancer.