AKT1 and neoplasm: Hatkevich showed that naringenin inhibits PI3K, thus disrupting proliferation signaling in MCF‐7 cells through ERK1/2, AKT, and MAPK signaling pathways,165 whereas α‐Mangostin mediated its anti‐tumor effect through decreasing HER2, Akt, and P13K along with increasing p‐p38 and p‐JNK1/2 phosphorylation.166