Chen et al. noted that Genistein (40–100 μM) exhibited anti‐proliferative activity by deactivating the IGF‐1R‐PI3K/Akt signaling pathway along with increasing Bax/Bcl‐2 expressions in MCF‐7 cells,104 whereas lycopene showed similar activities by increasing Bax expression without changing Bcl‐xL in MDA‐MB‐468 cancer cells.105. This evidence concerns the gene BAX and cancer.