MDM2 and neoplasm: MicroRNA (miRNA) regulates gene expression through incomplete complementary pairing with the 3' untranslated region of mRNAs involved in tumor progression.<h4>Methods</h4>In this study, bioinformatics analysis, RT-qPCR, dual-luciferase reporter gene, MTT, flow cytometry, cell scratches, chamber migration, colony formation, FISH, WB, and CCK8 were used.<h4>Results</h4>RT-qPCR showed that the expression of MDM2 was increased when miR-215-5p was overexpressed compared with the control group.