CACNA1C and cardiac arrhythmia: 25), which demonstrated that the strong implication of dysregulation of CACNA1C gene function in the arrhythmia phenotype. On the contrary, mutations with the LOF of Cav1.2 channel were found to exhibit shorter QT intervals (Ref. 26). Such evidence further demonstrated the important implication of CACNA1C in arrhythmia phenotype.