In contrast, when HUVECs were co‐cultured in the presence of BMP9‐overexpressing HBV‐infected HCC cell supernatant, a significant increase in the level of VE‐cadherin expression was observed compared to HUVECs co‐cultured with HBV‐uninfected HCC cell supernatant. Here, CDH5 is linked to hepatocellular carcinoma.