Eytan et al. queried the Cancer Genome Atlas and demonstrated that 60% of HNSCC cases (including HPV‐positive and ‐negative) had alterations in Fas‐associated death domain (FADD), baculoviral IAP repeat containing 2/3 (BIRC2/3, the genes encoding cIAP1/2), and/or caspase 8. This evidence concerns the gene BIRC2 and head and neck squamous cell carcinoma.