A retrospective study of 306 BRCA1/2 PV carriers followed up for up to 7.26 years after RRSO found no overall increased risk of breast cancer after 4 years of HRT; however, those who started HRT after age 45 years had a more than three-fold increased risk of breast cancer (odds ratio 3.43, p < 0.05, 95% CI 1.2–9.8).27 Whether this reflects higher risk of BC with age or is a direct effect of HRT is unknown. The gene discussed is BRCA1; the disease is breast cancer.