While IMCγ-IMCβ could not differentiate between the two SCA subtypes (AUC = 0.57), it had fair diagnostic ability differentiating SCA6 from neurotypical controls (AUC = 0.72) and good ability in differentiating SCA3 from neurotypical controls (AUC = 0.85; Fig. 3B). Here, CACNA1A is linked to autosomal dominant cerebellar ataxia.