For instance, a novel COL4A1 gene variant associated with CADASIL syndrome was recently found to be associated with GBM.[60] Moreover, the NOTCH3 gene (also associated with CADASIL syndrome) is a prognostic factor that promotes glioma cell proliferation, migration, and invasion.[61] Several drugs were identified as potential candidates for GBM, although they have not been clinically administered for GBM. Here, NOTCH3 is linked to cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1.