NOTCH3 and central nervous system cancer: For instance, a novel COL4A1 gene variant associated with CADASIL syndrome was recently found to be associated with GBM.[60] Moreover, the NOTCH3 gene (also associated with CADASIL syndrome) is a prognostic factor that promotes glioma cell proliferation, migration, and invasion.[61] Several drugs were identified as potential candidates for GBM, although they have not been clinically administered for GBM.