While we discovered here that the C. elegans WASP ortholog WSP-1 and the WASP regulator CDC-42 are required for the host antiviral defense (Fig. 4), Jiang et al reported that another C. elegans WASP ortholog VIRO-2 and the WASP regulator NCK-1 are required for virus infection (35). This evidence concerns the gene CDC42 and viral infectious disease.