FLOT1 and cancer: Interestingly, we found morphological changes from the typical spindle-like shape (mesenchymal morphology) of A549/X and H520/X cells to the cobblestone-like shape (epithelial morphology) of FLOT1 knockdown A549/X and H520/X cells (Figure 2b), suggesting that FLOT1 may endow cancer cells with EMT properties.