FH and renal cell carcinoma: According to the clonal phylogenetic trees and CNV-based phylogenetic trees, we observed that driver genes (such as FH and NF2) and CNV events (such as 9p loss and 22q loss) were involved in FH-RCC evolution (Fig. 2A, Additional file 3: Fig. S3 and Fig. S4) as previously reported [29].