Although similarly high levels of lymphocyte infiltration and cell cycle signal were found both in primary and metastatic lesions of FH-RCC, the enrichment of T effector cells and immune-related chemokines, together with immune checkpoint molecules (PD-1/PD-L1, TIGIT, and BTLA), were identified in metastatic lesions. The gene discussed is TIGIT; the disease is renal cell carcinoma.