Compared with paired primary lesions, the hypomethylated probes in metastatic lesions were enriched in genes involved in chemokine signaling, T cell receptor signaling, inflammatory response, Th1 and Th2 cell differentiation, cytokine-cytokine receptor interaction, IL2-STAT5 signaling, B cell receptor signaling pathway, PD-L1 expression, and PD-1 checkpoint pathway in cancer and Interferon-gamma response (Fig. 7C). The gene discussed is CD274; the disease is cancer.