UFL1 and Hepatic fibrosis: Compared with KO control mice, the levels of collagen I protein (a marker of liver fibrosis) were also profoundly elevated, underscored by a 6.43- and 4.15-fold increase in mRNA expression in Ufl1Δ/Δhep and Ufbp1Δ/Δhep mice, respectively (Fig. 2B and Supplementary Fig. S2A).