Therefore, the aim of the present study was to evaluate in a large group of NFAT patients: i) the possible association between metabolic consequences known to be associated with hypercortisolism, such as HT, DM, obesity (OB), dyslipidemia (DL) and CVE, and parameters of hypothalamic–pituitary–adrenal (HPA) axis activity (ACTH and F-1mgDST); ii) the cut-off of the HPA axis activity parameters able to identify NFAT patients with metabolic consequences. This evidence concerns the gene POMC and hematocrit.