JAG1 and neoplasm: By utilizing genetically engineered murine models of mammary-gland-specific Jagged1 overexpression or knockout mice, the researcher found that Notch activation by tumor-derived Jagged1 promoted the secretion of multiple cytokines (e.g., IL-6, WISP1) and TAM recruitment; the proliferation and tumoricidal activity of T cells were then inhibited, partially through upregulation of the T cells’ PD-1 [134].