However, in a different TME (e.g., in murine HCC or ovarian cancer), Notch signaling was regulated by a series of genes [e.g., transcriptional and immune response regulator (1810011O10 Rik, also known as TCIM) and enhancer of zeste homolog 2 (EZH2)] to modulate the anti-tumor immune response of T cells. Here, EZH2 is linked to hepatocellular carcinoma.