NOTCH3 and neoplasm: In addition, high expression of Notch3 was accompanied by increased expression of a series of ICs [e.g., CD276, adenosine Aa2a receptor (ADORA2A)], resulting in a dampened anti-tumor immune response [144]. In addition to solid tumors, abnormal expression of Notch signaling in tumor cells of hematologic malignancies can also affect the infiltration of immune cells.