TNF and neoplasm: Inhibition of Notch signaling not only promoted the cytotoxicity of tumor-infiltrating CD8+ T cells, but also enhanced CD8+ T cells’ production of proinflammatory cytokines [including IFN-γ, tumor necrosis factor alpha-like (TNF-α), interleukin-1 beta (IL-1β), IL-6, and IL-8] in those patients.