DLL4 and neoplasm: Compared with Dll4− DCs, these Dll4+ DCs can better promote the differentiation and expansion of T helper (Th) cells (e.g., Th1 and Th17 cells) and effector CD8+ T cells because they upregulate the transcription of differentiation-related transcription factors (e.g., GATA3, T-bet, RORC) and the production of anti-tumor effector cytokines (e.g., IL-4, IFN-γ, and IL-17).