By analyzing tumor samples from 152 patients with hormone receptor-positive and -negative phenotypes (luminal and triple-negative/basal-like) of BC, the author found that low mRNA levels of Notch receptors (mainly Notch1, Notch2, and Notch4) mainly in tumor cells were associated with higher infiltration of Treg cells into the tumors, predicting poor prognosis and poor survival [139]. This evidence concerns the gene NOTCH4 and neoplasm.