NOTCH3 and neoplasm: Another group also found that high Notch receptor (NOTCH3) expression was a poor prognostic factor when compared with 395 other genes in GC patients [144]. Specifically, high expression of Notch3 was associated with lower infiltration of anti-tumor immune cells (e.g., activated CD8+ T cells) and higher infiltration of immunosuppressive cells (e.g., Treg cells, M2-TAMs).