Of note, in vitro and in vivo tumor models (e.g., breast adenocarcinoma, lung cancer, thymoma) and three follow-up studies also demonstrated that activation of Notch signaling significantly enhanced the anti-tumor and/or anti-tumor memory capacity of CD8+ T cells by promoting the expression of IFN-γ and GZMB. The gene discussed is GZMB; the disease is neoplasm.