In summary, we analyzed the genetic landscape of glaucoma patients with cataract and ARC using bioinformatic methods, and the results showed that CTGF, FOS, CAV1, CYR61, ICAM1, EGR1, and NR4A1 may be involved in cataract progression under high IOP; however, further studies are needed to fully understand their underlying molecular mechanisms. This evidence concerns the gene CCN2 and glaucoma.