Our findings expand on the knowledge of the regulatory mechanisms of neutrophil PD-L1 expression under septic conditions, which remain underexplored with only two studies highlighting the role of spleen-derived IFN-γ [65, 66] and another highlighting the involvement of the p38α-MSK1/MK2 pathway in the generation of PD-L1+ neutrophils during sepsis [26]. This evidence concerns the gene RPS6KA5 and Sepsis.