The role of PD-L1 on sepsis-induced liver injury remains less explored, with one study identifying a therapeutic role for anti-PD-L1 antibodies on liver damage in a CLP model [77] and another demonstrating that PD-L1 can cause liver sinusoidal endothelial cell damage by interacting with PD-1 on Kupffer cells [78]. This evidence concerns the gene CD274 and Sepsis.