CCNO and pleural mesothelioma: Since TTFields (in addition to and independent of their anti-mitotic effects) have been shown to impair DNA damage repair and promote accumulation of DNA double strand breaks in non-small cell lung cancer (NSCLC) and pleural mesothelioma cell lines [28, 29, 32], and as TMZ and CCNU are DNA alkylating agents, we next examined the effect of these modalities on DNA damage and repair in GBM cells.