The role of SIRT1 in MS in experimental research is a matter of debate; numerous investigations reported that SIRT1 activation can ameliorate the course of the disease and improve neurological functions by targeting several neuroprotective pathways [32], whereas, in other studies, remyelination and neuroprotection were seen following SIRT1 inhibition [28]. The gene discussed is SIRT1; the disease is myeloid sarcoma.