It is noteworthy that a suggestive signal was also observed for ADAM10. Several important conclusions can be drawn from this work: (i) rare, damaging variants in these genes have a large effect on the AD risk; (ii) unsurprisingly, these variants are enriched in early-onset AD; (iii) all these genes with rare variants have been associated with the AD risk in GWASs of common variants. The gene discussed is ADAM10; the disease is Alzheimer disease.