The slow-release feature of the LDH@aPD-1@CC patch could long-termly maintain a high proportion of memory CD8+ T cells (both Tem+ and Tcm+, Fig. 5g) in the SLN, especially CD8+ T cells with antigen-specific immune memory (CD44+H-2Ld SPSYVYHQF pentamer+, Fig. 5j), fighting against cancer resurgence. This evidence concerns the gene CD44 and cancer.