G3 MB tumors commonly maintain WT TP53, and we found that upon IACS-010759-mediated downregulation of MYC, MILIP transcript levels were also suppressed and this corresponded with an increase in WT TP53 protein levels, which in turn may offer an additional desirable therapeutic benefit for suppressing tumor growth (Fig. 3A, B). Here, TP53 is linked to neoplasm.