In further support of this notion, we found that 100 nM IACS-010759 treatment significantly decreased the abundance of MYC in various types of cancer cells from MYC-activated ovarian (A2780 and HEYA8), colorectal (HCT116 and SW480), and breast (MDA-MB-468) cancer cell lines (Supplementary Fig. 3A). Here, MYC is linked to cancer.