For example, KLF5 and p53 coordinately regulate NOTCH1 to suppress malignant transformation in normal squamous epithelial cells [13], and KLF5 and p53 also functionally interact in cancer cells, regulating HIF1α expression in colon cancer [15] and survivin expression in acute lymphoblastic leukemia [14]. The gene discussed is TP53; the disease is malignant colon neoplasm.