Reportedly, exposure to small-molecule compounds, such as NSC 19630 (N-(1-(4-((4-methoxyphenyl) amino) quinazolin-6-yl) ethyl)-3-(pyridin-3-yl) acrylamide) and NSC 617145 (5-(4-chlorophenyl)-4-(4-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine N-(4-methylphenyl) sulfonylacetamide), which inhibits WRN helicase activity, sensitizes cancer cells to DNA-damaging agents [39] and DNA cross-linking agents [40]. This evidence concerns the gene WRN and cancer.