MYC and acute myeloid leukemia: To exclude the influence of endogenous TMEM134 protein, we generated a Tmem134 knockout Myc AML monoclonal cell line (i.e., M#8) with CRISPR/Cas9 and then introduced TMEM134α or TMEM134β cDNA into M8# by retrovirus (S9C–S9G Fig).