As expected, we found that these subpopulations displayed distinguishable gene signatures in the TCGA_LAML and TARGET_AML databases, and the hazard ratio calculated that the HSP90AA1hi subtype was significantly associated with high risk in human AML patients and HSP90AA1 expressions were up-regulated in even most malignancies (S6G–S6K Fig). The gene discussed is HSP90AA1; the disease is acute myeloid leukemia.