KCNJ11 and Hyperglycemia: In response to hyperglycemia, Kir6.2+/+ APP/PS1 mice also showed a 210% increase in plasma insulin compared with fasting levels (P = 0.002), while no change on plasma insulin levels was observed in Kir6.2–/– APP/PS1 mice (P = 0.8976; Figure 4B).