APP and Hyperglycemia: Reduced insulin secretion in Kir6.2–/– APP/PS1 mice was also accompanied by higher blood glucose levels during the first 2 hours of the clamp (Figure 4C) and a 68% reduction in glucose infusion rates, a metric of insulin responsiveness to hyperglycemia, compared with Kir6.2+/+ APP/PS1 mice during the hyperglycemic clamp (P = 0.0003; Figure 4D).