APP and Alzheimer disease: To explore the role of Kir6.2-dependent KATP channels in AD-related pathology, we crossed mice deficient in Kir6.2 (i.e., Kir6.2–/– mice) (33) with APPswe/PSEN1dE9 (i.e., APP/PS1) (36) mice to generate mice overexpressing Aβ that were also deficient in neuronal KATP channel activity (i.e., Kir6.2–/– APP/PS1).