Leveraging a similar publicly available scRNA-Seq data set generated from blood B cells of HDs (n = 3), patients with HIV (n = 3), and patients with malaria (n = 3), published by Holla et al. (35), we first identified total CD27+ITGAX–, CD27–ITGAX+, and CD27+ITGAX+ B cells from all groups, which should collectively represent BCR-experienced memory subsets. Here, CD27 is linked to malaria.