Interestingly, the GEPIA (http://gepia.cancer-pku.cn/) and The Human Protein Atlas (HTTPS://www.proteinatlas.org/) databases revealed that the expressions of PIK3CA, AKT1, and GSK3B in HCC tissues were enhanced (compared with those of normal liver tissues) (Supplementary Fig. 1A–G). The gene discussed is PIK3CA; the disease is hepatocellular carcinoma.