The National Comprehensive Cancer Network (NCCN) guideline version 2.2020 for ALL recommends the evaluation of recurrent genetic and molecular characterization of ALL by using karyotyping of G-banded chromosome analysis, FISH studies for the major recurrent genetic abnormalities, and RT-PCR for BCR-ABL1 (p190 and p210) [38]. The gene discussed is CNTNAP1; the disease is acute lymphoblastic leukemia.