CRLF2 and acute lymphoblastic leukemia: Furthermore, the GATA3 rs3824662 gene risk allele was identified as a susceptibility locus for Ph-like ALL according to the observation of Perez Andreu et al., and others that the ALL patients who harbored GATA3 rs3824662 gene risk allele were associated with CRLF2 overexpression, JAK mutation, IKZF1 rearrangement, and those patients had a higher risk of relapse [26, 27].