Ph-like ALL may harbor different molecular alterations including (i) rearrangements of CRLF2 (cytokine receptor-like factor 2 receptor), which is the most common; (ii) ABL-class rearrangements; (iii) JAK2, and/or EPOR rearrangements; (iv) other mutation in JAK/STAT signaling; (v) other kinase mutations such as FLT3, NTRK3, PTK2B, and BLNK genes; and (vi) RAS mutations [10, 11]. Here, PTK2B is linked to acute lymphoblastic leukemia.