EVPL and acute lymphoblastic leukemia: The National Comprehensive Cancer Network (NCCN) guideline version 2.2020 for ALL recommends the evaluation of recurrent genetic and molecular characterization of ALL by using karyotyping of G-banded chromosome analysis, FISH studies for the major recurrent genetic abnormalities, and RT-PCR for BCR-ABL1 (p190 and p210) [38].