BCR-ABL-like ALL belongs to the high-risk group of B-ALL in addition to KMT2A (MLL) translocations, low hypodiploidy (30–39 chromosomes), near haploidy (<30 chromosomes), BCR-ABL1, intrachromosomal amplification of chromosome 21 (iAMP21), t(17;19)/TCF3-HLF fusion, and complex karyotype [38, 39]. The gene discussed is HLF; the disease is acute lymphoblastic leukemia.