EGFR and neoplasm: ANXA6 is generally considered a tumor suppressor gene, mainly because ANXA6 negatively regulates epidermal growth factor receptor (EGFR) phosphorylation and its downstream the Ras-Raf-mitogen activated protein kinases (MAPK) and phosphatidylinositol-3-kinase/Akt (PI3K-AKT) pathway, which are two important signals for tumorigenesis, thereby affecting a variety of tumor-associated phenotypes, as is shown in the Fig. 1 [35–38].