CHAF1B and cervical squamous intraepithelial neoplasia: We conclude that CENP-A is mislocalized in parental HeLa and HeLaCENP-A–TAP cells depleted for CHAF1B and that increased levels of mislocalized CENP-A contribute to CIN phenotypes upon CHAF1B depletion in HeLaCENP-A–TAP cells.