Similar to results obtained in budding yeast, we have shown that the mislocalization of overexpressed CENP-A contributes to CIN in aneuploid (HeLa), diploid (RPE1) and pseudodiploid (DLD1) human cell lines (Shrestha et al., 2017, 2021). Here, CENPA is linked to cervical squamous intraepithelial neoplasia.