Programmed death ligand 1 (PD‐L1) is considered a key regulator of tumor‐related immunosuppression and tumor progression, and it has been used as a therapeutic target in the clinical treatment of solid tumors.[257] 2D‐NBFFs, such as MOF and COF could be used to load, protect, and deliver small interfering ribonucleic acid, which avoids the degradation of small interfering ribonucleic acid by enzymatic. This evidence concerns the gene CD274 and neoplasm.