2020). Increased generation of pro-inflammatory cytokine secretion of IL-1β and IL-18 in nonalcoholic steatohepatitis (NASH) mice (Du et al. 2019). Similarly, the levels of NF-κB and IL-1β are upregulated in our IR/D rats. NF-κB signaling pathway has been reported to regulate diabetes mellitus-induced placental or retinal oxidative stress and inflammation (Liu et al. 2020; Shi et al. 2020). Furthermore, NF-κB and Wnt1/β-catenin signaling pathways participate in the regulation of type 2-induced diabetic liver injury in male rats (Bashar et al. 2021). Here, IL18 is linked to metabolic dysfunction-associated steatohepatitis.