Stress hyperglycemia at admission is associated with elevated plasma IL 18, CRP level, cytotoxic T cells, CD16+/ CD 56+ percentage, and CD4/CD8 ratio while inhibitors of T-cell activation like CD152 level is reduced implicating the role of inflammation in limiting the immune response of ischemia in STEMI. The gene discussed is CTLA4; the disease is Hyperglycemia.