In this context, four phytochemicals Curcumin [46], derived from Curcuma longa; Resveratrol [47], from Vitis vinifera; Quercetin [48], from Sophora japonica; and Pepperlongumene [49], from Piper longum, were studied and tested against cancer as a part of the EGFR-TKIs class. The gene discussed is EGFR; the disease is cancer.