EGFR and neoplasm: However, the receptor regulates many signaling pathways in the body, with the absence or low expression of EGFR and other receptor tyrosine kinases in humans leading to many diseases such as Alzheimer's disease [37,38], while overexpression of EGFR-TKD is linked to the development of many tumor diseases, including breast and lung cancers, which are currently the most lethal [35].